Diseases of the respiratory tract such as emphysema, bronchitis, asthma and cystic fibrosis are affect a wide range of people. These respiratory tract diseases are the second leading cause of death worldwide. More than 35 million Americans suffer from chronic respiratory disease.
Weizmann Institute scientists are researching on embryonic stem cells and their use to relieve the the sufferers of the respiratory disorders. The stem cells are believed to repair the damaged tissue of the inner lining of lungs.
Let us talk about the insight that led to the very hypothesis and possible use of stem cells. Scientists observed that stem cells found in the lungs of the human body are similar to those in the bone marrow. Also, each organ of the human body has special compartments where the stem cells reside. These are not distribute throughout the tissue. The understanding of bone marrow transplant thus could be replicated to repair the lung tissue.
Prof. Yair Reisner of the Weizmann Institute’s Immunology Department says: “That understanding suggested to us that we might be able to apply our knowledge of techniques for transplanting bone marrow stem cells to repairing lung tissue.”
It was important to understand the principles of bone marrow transplant for this hypothesis. Bone marrow transplant is based on two main principles: the ability of stem cells to travel through the blood to the appropriate compartment and the prior clearing out of the compartment to make space for the transplanted stem cells. Reisner and his group thought the same could be applied to introduce new stem cells into the lungs.
Further research helped them understand that embryonic stem cells from the 20th -22nd week are suitable for this kind of transplant in the lungs. The team then conducted a series of experiments in which they cleared the lung’s stem cell compartments with a method they had devised. The new stem cells were then injected into mouse models of lung damage. The embryonic lung stem cells which were injected managed to find their way through the blood to the lungs and settle into the appropriate compartment. Within six weeks, these stem cells were differentiating into normal lung tissue. The damaged lungs healed in the mice, and their breathing showed a significant improvement.
More such researches are a boon to diseases of the respiratory tract. Researches not just help diagnose the diseases but also study the symptoms in detail. Researches also help the drug industries identify the best possible drugs for the cure of the disease or improvise the existing ones for better cure. More insights in pipeline for the respiratory disorders are available as elaborately analysed reports on http://emarketorg.com/tag/pipeline-insights/ . These reports have comprehensively analysed data of competitor pipeline molecules, related research activities, technology and much more. These research insights translated to actual commercial use for the sufferers of the respiratory disorders is much needed.